Entry Detail

General Information

Database ID: LDA0018645
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG5
Full Name:small nucleolar RNA host gene 5
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf160|LINC00044|NCRNA00044|U50HG
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):85677007End Site(bp):85678733
External Links:
Ensembl ID:ENSG00000203875
Ensembl Transcript ID:ENSG00000203875
Entrez Gene:387066.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:44
Network:
Top Causal Diseases:
Glioma  (Score: 0.999893)
Glioma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.731059)
Melanoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:824D010518
Disease Name:periodontitisPeriodontitis
Category:Disease OntologyMeSH
Type:Stomatognathic Diseases
Define:Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Alias:chronic pericementitisPeriodontitis//Periodontitides//Pericementitis//Pericementitides

 

Disease Association Statistics

Total Associated ncRNA Number:22   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
hsa_circ_0138959  (Score: 0.731059)
hsa_circ_0099630  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
Nron  (Score: 0.731059)
hsa_circ_0138959  (Score: 0.731059)
hsa_circ_0099630  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
Nron  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35713268
Disease Name:Periodontitis
Sample:human and mouse periodontal tissues
Dysfunction Pattern:Regulation(NF-κB )
Validated Method:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Description: SNHG5 expression was down-regulated in human and mouse periodontal tissues compared to that in the healthy controls. In vitro experiments demonstrated that SNHG5 significantly ameliorated tumour necrosis factor α-induced inflammation. Mechanistically, SNHG5 directly binds to the nuclear factor-kappa B (NF-κB) p65 subunit and inhibits its translocation, thereby suppressing the NF-κB signalling pathway activation and reducing the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing three inflammasome expression. Locally injecting si-SNHG5 aggravated the periodontal destruction.
Causality:No
Causal Description:
Clinical-realted Application: