Entry Detail

General Information

Database ID: LDA0018836
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RUNX1
Full Name:RUNX family transcription factor 1
Category:LncRNA
Species:Homo sapiens
Synonyms:AML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha
Chromosome:21
Strand:-
Coordinate:
Start Site(bp):34787801End Site(bp):35049302
External Links:
Ensembl ID:ENSG00000159216
Ensembl Transcript ID:N/A
Entrez Gene:861.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8924D016553
Disease Name:autoimmune thrombocytopenic purpuraPurpura, Thrombocytopenic, Idiopathic
Category:Disease OntologyMeSH
Type:Hemic and Lymphatic Diseases
Define:A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies.Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.
Alias:Immune thrombocytopenic purpura//idiopathic thrombocytopenic purpura//primary thrombocytopenic purpuraPurpura, Thrombocytopenic, Idiopathic//Idiopathic Thrombocytopenic Purpura//Idiopathic Thrombocytopenic Purpuras//Purpura, Idiopathic Thrombocytopenic//Purpuras, Idiopathic Thrombocytopenic//Thrombocytopenic Purpura, Idiopathic//Thrombocytopenic Purpuras, Idiopathic//Immune Thrombocytopenic Purpura//Immune Thrombocytopenic Purpuras//Purpura, Immune Thrombocytopenic//Purpuras, Immune Thrombocytopenic//Thrombocytopenic Purpura, Immune//Thrombocytopenic Purpuras, Immune//Immune Thrombocytopenia//Immune Thrombocytopenias//Thrombocytopenia, Immune//Thrombocytopenias, Immune//Thrombocytopenic Purpura, Autoimmune//Werlhof Disease//Disease, Werlhof//Werlhof's Disease//Disease, Werlhof's//Werlhofs Disease//Autoimmune Thrombocytopenia//Autoimmune Thrombocytopenias//Thrombocytopenia, Autoimmune//Thrombocytopenias, Autoimmune//Autoimmune Thrombocytopenic Purpura//Autoimmune Thrombocytopenic Purpuras//Purpura, Autoimmune Thrombocytopenic//Purpuras, Autoimmune Thrombocytopenic//Purpura, Thrombocytopenic, Autoimmune

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.731059)
PVT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:36731007
Disease Name:Purpura, Thrombocytopenic, Idiopathic
Sample:100 patients with newly diagnosed ITP
Dysfunction Pattern:Expression(highly expressed)
Validated Method:qRT-PCR
Description:GAS5 was under-expressed, while RUNX1 was over-expressed among the newly diagnosed ITP children compared with the control group.
Causality:No
Causal Description:
Clinical-realted Application:The best cut-off values of GAS5 and RUNX1 expression that predict chronic ITP were ?0.17 and ?4.1, respectively, yielding sensitivity of 88.89% and 77.78%, respectively. GAS5 and RUNX1 could be useful markers in children with primary ITP to predict disease course.