LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0018839
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Unknown
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

RUBCNL

Full Name:

rubicon like autophagy enhancer

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

C13orf18|KIAA0226L|PACER

Chromosome:

Strand:

Coordinate:

Start Site(bp):

46334681

End Site(bp):

46390042

External Links:

Ensembl ID:	ENSG00000102445
Ensembl Transcript ID:	N/A
Entrez Gene:	80183.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

10 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Colorectal Neoplasms (Score: 0.731059)

Pulmonary Disease, Chronic Obstructive (Score: 0.731059)

Colorectal Neoplasms (Score: 0.731059)

Pulmonary Disease, Chronic Obstructive (Score: 0.731059)

Mycoplasma Pneumoniae-Induced Inflammatory (Score: 0.548294)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:1324	D008175
Disease Name:	lung cancer	Lung Neoplasms
Category:	Disease Ontology	MeSH
Type:		Neoplasms
Define:	A respiratory system cancer that is located_in the lung.	Tumors or cancer of the LUNG.
Alias:		Lung Neoplasms//Pulmonary Neoplasms//Neoplasms, Lung//Lung Neoplasm//Neoplasm, Lung//Neoplasms, Pulmonary//Neoplasm, Pulmonary//Pulmonary Neoplasm//Lung Cancer//Cancer, Lung//Cancers, Lung//Lung Cancers//Pulmonary Cancer//Cancer, Pulmonary//Cancers, Pulmonary//Pulmonary Cancers//Cancer of the Lung//Cancer of Lung

Disease Association Statistics

Total Associated ncRNA Number:

344 More Information

Causal ncRNA Number:

282

Network:

Top Causal ncRNAs:

OIP5-AS1 (Score: 0.999893)

MNX1-AS1 (Score: 0.999893)

NEAT1 (Score: 0.999893)

MNX1-AS1 (Score: 0.999893)

NEAT1 (Score: 0.999893)

circHIPK3 (Score: 0.985791)

GAS5 (Score: 0.985791)

PCAT1 (Score: 0.985791)

NNT-AS1 (Score: 0.985791)

More Information

Evidence Support

Strong Evidence:	qRT-PCR
Weak Evidence:

Reference

[1] PubMed ID:	35136486
Disease Name:	Lung Neoplasms
Sample:	lung adenocarcinomas tissues
Dysfunction Pattern:	Regulation(COX-2)
Validated Method:	qRT-PCR
Description:	Our analysis of The Cancer Genome Atlas (TCGA) expression data revealed that PACER expression is significantly higher in lung adenocarcinomas than normal lung tissues. Additionally, we discovered that elevated PACER expression strongly correlates with COX-2 expression in lung adenocarcinoma patients. Specific siRNA-mediated knockdown of PACER decreases COX-2 expression indicating a direct relationship.
Causality:	No
Causal Description:
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail