Entry Detail

General Information

Database ID: LDA0021004
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DSCR8
Full Name:Down syndrome critical region 8
Category:LncRNA
Species:Homo sapiens
Synonyms:C21orf65|CT25.1a|CT25.1b|MMA-1|MMA-1a|MMA-1b|MMA1|MTAG2
Chromosome:21
Strand:+
Coordinate:
Start Site(bp):38121451End Site(bp):38156511
External Links:
Ensembl ID:ENSG00000198054
Ensembl Transcript ID:N/A
Entrez Gene:84677.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:684D006528
Disease Name:hepatocellular carcinomaCarcinoma, Hepatocellular
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Alias:HepatomaCarcinoma, Hepatocellular//Carcinomas, Hepatocellular//Hepatocellular Carcinomas//Liver Cell Carcinoma, Adult//Liver Cancer, Adult//Adult Liver Cancer//Adult Liver Cancers//Cancer, Adult Liver//Cancers, Adult Liver//Liver Cancers, Adult//Liver Cell Carcinoma//Carcinoma, Liver Cell//Carcinomas, Liver Cell//Cell Carcinoma, Liver//Cell Carcinomas, Liver//Liver Cell Carcinomas//Hepatocellular Carcinoma//Hepatoma//Hepatomas

 

Disease Association Statistics

Total Associated ncRNA Number:1438   
More Information
Causal ncRNA Number:1176
Network:
Top Causal ncRNAs:
LINC00467  (Score: 1)
SNHG6  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
DANCR  (Score: 1)
ST8SIA6-AS1  (Score: 1)
SNHG6  (Score: 1)
ZFPM2-AS1  (Score: 1)
CDKN2B-AS1  (Score: 1)
TUG1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:30154476
Disease Name:Carcinoma, Hepatocellular
Sample:HCC tissues and cell lines
Dysfunction Pattern:Regulation[DSCR8/miR-485-5p/FZD7 axis]
Validated Method:Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining
Description: In this study, real-time PCR in HCC tissues and cell lines indicated that DSCR8 expression was upregulated, while miR-485-5p was downregulated.Taken together, the present study reports for the first time that DSCR8 activates Wnt/β-catenin signal pathway to promote HCC progression by DSCR8/miR-485-5p/FZD7 axis.
Causality:No
Causal Description:
Clinical-realted Application: