Entry Detail


General Information

Database ID: LDA0021006
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DSCAM-AS1
Full Name:DSCAM antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:M41
Chromosome:21
Strand:+
Coordinate:
Start Site(bp):40383083End Site(bp):40385358
External Links:
Ensembl ID:ENSG00000235123
Ensembl Transcript ID:N/A
Entrez Gene:100506492.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:30   
More Information
Causal Disease Number:24
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Colonic Neoplasms  (Score: 0.731059)
endometrial adenocarcinoma  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Melanoma  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050861
Disease Name:colorectal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A colorectal carcinoma that derives_from epithelial cells of glandular origin.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
AK077216  (Score: 0.731059)
AWPPH  (Score: 0.731059)
PCED1B-AS1  (Score: 0.731059)
MNX1-AS1  (Score: 0.731059)
MEG3  (Score: 0.731059)
AK077216  (Score: 0.731059)
AWPPH  (Score: 0.731059)
PCED1B-AS1  (Score: 0.731059)
MNX1-AS1  (Score: 0.731059)
MEG3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31686837
Disease Name:colorectal adenocarcinoma
Sample:CRA tissues
Dysfunction Pattern:Interaction[downregulates miR-216b]
Validated Method:qRT-PCR//Transwell Assay//Western Blot
Description:It was observed that DSCAM-AS1 was upregulated in the primary tumor tissues than in paired non-tumor tissues (within 2 cm around tumors) and was further increased with tumor metastasis. miR-216b was downregulated in primary tumor and further downregulated with tumor metastasis. miR-216b was inversely correlated with DSCAM-AS1 in tumor tissues, but not in non-tumor tissues. In cells of CRA cell lines, DSCAM-AS1 overexpression resulted in the downregulation of miR-216b, while miR-216b overexpression did not significantly affect DSCAM-AS1. miR-216b inhibited cancer cell migration and invasion and significantly reduced the effects of DSCAM-AS1 overexpression. Methylation-specific PCR showed that DSCAM-AS1 overexpression promoted the methylation of miR-216b gene.
Causality:No
Causal Description:
Clinical-realted Application: