Entry Detail

General Information

Database ID: LDA0021009
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:EGFR-AS1
Full Name:EGFR antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):55179750End Site(bp):55188949
External Links:
Ensembl ID:ENSG00000224057
Ensembl Transcript ID:N/A
Entrez Gene:100507500.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Kidney Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1967D007890
Disease Name:leiomyosarcomaLeiomyosarcoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)
Alias:LeiomyosarcomasLeiomyosarcoma//Leiomyosarcomas//Leiomyosarcoma, Epithelioid//Epithelioid Leiomyosarcoma//Epithelioid Leiomyosarcomas//Leiomyosarcomas, Epithelioid//Leiomyosarcoma, Myxoid//Leiomyosarcomas, Myxoid//Myxoid Leiomyosarcoma//Myxoid Leiomyosarcomas

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//IF//IHC//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:35485964
Disease Name:Leiomyosarcoma
Sample:LMS tissues
Dysfunction Pattern:Interaction(EGFR-AS1)
Validated Method:In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//IHC//IF
Description:up-regulation of EGFR-AS1 and PD-L1 in LMS tissues was negatively correlated with CD8+ T-cell infiltration; EGFR-AS1 positively regulated PD-L1, thereby strengthening interaction of LMS cells and CD8+ T cells and triggering CD8+ T cell apoptosis via the PD-1/PD-L1 checkpoint; EGFR-AS1 co-localized and interacted with EGFR to promote MYC activity; MYC was identified as a transcriptional activator of PD-L1.
Causality:No
Causal Description:
Clinical-realted Application: