Entry Detail

General Information

Database ID: LDA0021138
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ESS2
Full Name:ess-2 splicing factor homolog
Category:LncRNA
Species:Homo sapiens
Synonyms:DGCR13|DGCR14|DGS-H|DGS-I|DGSH|DGSI|ES2|ESS-2|Es2el|bis1
Chromosome:22
Strand:-
Coordinate:
Start Site(bp):19130279End Site(bp):19144651
External Links:
Ensembl ID:ENSG00000100056
Ensembl Transcript ID:N/A
Entrez Gene:8220.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1612D001943
Disease Name:breast cancerBreast Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A thoracic cancer that originates in the mammary gland.Tumors or cancer of the human BREAST.
Alias:breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary tumor//primary breast cancerBreast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

 

Disease Association Statistics

Total Associated ncRNA Number:1186   
More Information
Causal ncRNA Number:766
Network:
Top Causal ncRNAs:
MILIP  (Score: 1)
GAS5  (Score: 1)
MILIP  (Score: 1)
H19  (Score: 1)
CDKN2B-AS1  (Score: 1)
DANCR  (Score: 1)
AFAP1-AS1  (Score: 1)
CDKN2B-AS1  (Score: 1)
NEAT1  (Score: 1)
circHIPK3  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Flow Cytometry//qRT-PCR//MTT
Weak Evidence:

 

Reference

[1] PubMed ID:31211468
Disease Name:Breast Neoplasms
Sample:breast cancer tissues
Dysfunction Pattern:Interaction[HER2]
Validated Method:Flow Cytometry//qRT-PCR//MTT
Description:In the current research, we found ES3 upregulation in breast cancer and its diagnostic value in breast cancer diagnosis. In addition, our data demonstrated that ES3 expression downregulated during neural differentiation. Therefore, its expression may be correlated to breast tumor differentiation status. Notably, a high expression level of ES3 in HER2-positive breast tumor tissues motivated us to investigate the effect of HER2 on ES3 expression by blocking HER2 activity with lapatinib. The results showed that ES3 expression suppressed when HER2 activity was blocked. In summary, for the first time, we found that lncRNA ES3 was significantly upregulated in HER2-positive breast tumors and may contribute to breast cancer proliferation as a downstream target of HER2.
Causality:No
Causal Description:
Clinical-realted Application:Furthermore, our findings revealed that ES3 transcript has a high expression in high-grade and high-stage breast tumors.