Entry Detail

General Information

Database ID: LDA0021360
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DANCR
Full Name:Angelman syndrome chromosome region
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:ENSG00000226950
Ensembl Transcript ID:N/A
Entrez Gene:282.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:62   
More Information
Causal Disease Number:54
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11476D010024
Disease Name:osteoporosisOsteoporosis
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
Alias:Osteoporosis//Osteoporoses//Osteoporosis, Post-Traumatic//Osteoporosis, Post Traumatic//Post-Traumatic Osteoporoses//Post-Traumatic Osteoporosis//Osteoporosis, Senile//Osteoporoses, Senile//Senile Osteoporoses//Osteoporosis, Involutional//Senile Osteoporosis//Osteoporosis, Age-Related//Osteoporosis, Age Related//Bone Loss, Age-Related//Age-Related Bone Loss//Age-Related Bone Losses//Bone Loss, Age Related//Bone Losses, Age-Related//Age-Related Osteoporosis//Age Related Osteoporosis//Age-Related Osteoporoses//Osteoporoses, Age-Related

 

Disease Association Statistics

Total Associated ncRNA Number:32   
More Information
Causal ncRNA Number:20
Network:
Top Causal ncRNAs:
KCNQ1OT1  (Score: 0.985791)
hsa_circ_0002060  (Score: 0.985791)
hsa_circ_0002060  (Score: 0.985791)
KCNQ1OT1  (Score: 0.985791)
Mir22hg  (Score: 0.731059)
TERC  (Score: 0.731059)
WT1-AS  (Score: 0.731059)
PTCSC3  (Score: 0.731059)
AWPPH  (Score: 0.731059)
CCAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:32778797
Disease Name:Osteoporosis
Sample:Human BMSCs
Dysfunction Pattern:regulation[Wnt/β-catenin signaling pathway]
Validated Method:qRT-PCR//Luciferase Report Assay//Western Blot
Description: The expression levels of DANCR and miR-320a in BMSCs derived from osteoporosis patients were upregulated, whereas CTNNB1 expression was downregulated compared with that in healthy controls.Taken together, our findings revealed that DANCR and miR-320a regulated the Wnt/β-catenin signaling pathway during osteogenic differentiation in osteoporosis through CTNNB1 inhibition.
Causality:No
Causal Description:
Clinical-realted Application: