Entry Detail

General Information

Database ID: LDA0021457
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript
Category:LncRNA
Species:Mus musculus
Synonyms:EyeLinc6
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):142129267End Site(bp):142131883
External Links:
Ensembl ID:ENSMUSG00000000031
Ensembl Transcript ID:N/A
Entrez Gene:14955.0
NONCODE ID:N/A
RefSeq Accession:NR_130973.1

 

ncRNA Association Statistics

Total Associated Disease Number:214   
More Information
Causal Disease Number:122
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Glioma  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050861
Disease Name:colorectal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A colorectal carcinoma that derives_from epithelial cells of glandular origin.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
AK077216  (Score: 0.731059)
AWPPH  (Score: 0.731059)
PCED1B-AS1  (Score: 0.731059)
MNX1-AS1  (Score: 0.731059)
MEG3  (Score: 0.731059)
AK077216  (Score: 0.731059)
AWPPH  (Score: 0.731059)
PCED1B-AS1  (Score: 0.731059)
MNX1-AS1  (Score: 0.731059)
MEG3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30278464
Disease Name:colorectal adenocarcinoma
Sample:CRA and adjacent normal tissues
Dysfunction Pattern:Regulation[H19/miR-194/FoxM1 axis]
Validated Method:qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay
Description: Highly-expressed H19, lowly-expressed miR-194-5p, low-grade differentiation and lymph node metastasis appeared as the independent predictors of unfavorable prognosis in CRA patients' (all P< 0.05).LncRNA H19/miR-194/FoxM1 axis could serve as a profound target for the diagnosis and treatment of CRA.
Causality:No
Causal Description:
Clinical-realted Application: Highly-expressed H19, lowly-expressed miR-194-5p, low-grade differentiation and lymph node metastasis appeared as the independent predictors of unfavorable prognosis in CRA patients' (all P< 0.05).