Entry Detail

General Information

Database ID: LDA0021526
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript
Category:LncRNA
Species:Mus musculus
Synonyms:EyeLinc6
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):142129267End Site(bp):142131883
External Links:
Ensembl ID:ENSMUSG00000000031
Ensembl Transcript ID:N/A
Entrez Gene:14955.0
NONCODE ID:N/A
RefSeq Accession:NR_130973.1

 

ncRNA Association Statistics

Total Associated Disease Number:214   
More Information
Causal Disease Number:122
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Glioma  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0080208D065626
Disease Name:non-alcoholic fatty liver diseaseNon-alcoholic Fatty Liver Disease
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:A fatty liver disease characterized by the storing of excess fat in liver cells which is not caused by heavy alcohol use.Fatty liver finding without excessive ALCOHOL CONSUMPTION.
Alias:NAFLDNon-alcoholic Fatty Liver Disease//Non alcoholic Fatty Liver Disease//NAFLD//Nonalcoholic Fatty Liver Disease//Fatty Liver, Nonalcoholic//Fatty Livers, Nonalcoholic//Liver, Nonalcoholic Fatty//Livers, Nonalcoholic Fatty//Nonalcoholic Fatty Liver//Nonalcoholic Fatty Livers//Nonalcoholic Steatohepatitis//Nonalcoholic Steatohepatitides//Steatohepatitides, Nonalcoholic//Steatohepatitis, Nonalcoholic

 

Disease Association Statistics

Total Associated ncRNA Number:82   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
NEAT1  (Score: 1)
Gas5  (Score: 0.985791)
Gas5  (Score: 0.985791)
RMRP  (Score: 0.731059)
hsa_circ_0057558  (Score: 0.731059)
Pvt1  (Score: 0.731059)
PTK2  (Score: 0.731059)
hsa_circ_0001805  (Score: 0.731059)
Platr4  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Oil Red O Staining//ELISA//IHC
Weak Evidence:

 

Reference

[1] PubMed ID:31064820
Disease Name:Non-alcoholic Fatty Liver Disease
Sample:liver tissues,cell lines
Dysfunction Pattern:Regulation[miR-130a/PPARγ axis]
Validated Method:RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Oil Red O Staining//ELISA//IHC
Description:H19 and PPARγ were up-regulated, while miR-130a was down-regulated in NAFLD mouse and cellular model.Knockdown of H19 inhibited steatosis and TG secretion in FFA-induced hepatocytes. H19 could bind to miR-130a, and miR-130a could directly inhibit PPARγ expression. Meanwhile, miR-130a inhibited lipid accumulation by down-regulating NAFLD-related genes PPARγ, SREBP1, SCD1, ACC1 and FASN. Overexpression of miR-130a and PPARγ antagonist GW9662 inhibited lipogenesis and TG secretion, and PPARγ agonist GW1929 reversed this change induced by miR-130a up-regulation.
Causality:No
Causal Description:
Clinical-realted Application: