Entry Detail

General Information

Database ID: LDA0021538
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript
Category:LncRNA
Species:Mus musculus
Synonyms:EyeLinc6
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):142129267End Site(bp):142131883
External Links:
Ensembl ID:ENSMUSG00000000031
Ensembl Transcript ID:N/A
Entrez Gene:14955.0
NONCODE ID:N/A
RefSeq Accession:NR_130973.1

 

ncRNA Association Statistics

Total Associated Disease Number:214   
More Information
Causal Disease Number:122
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Glioma  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:13189D015210
Disease Name:goutArthritis, Gouty
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:An arthritis that has_material_basis_in uric acid crystal deposits located_in joint.Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular. Acute and chronic gouty arthritis are associated with accumulation of MONOSODIUM URATE in and around affected joints.
Alias:Articular gout//Gouty arthropathy//gouty arthritisArthritis, Gouty//Gouty Arthritis//Arthritides, Gouty//Gouty Arthritides

 

Disease Association Statistics

Total Associated ncRNA Number:46   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
Slco3a1-206  (Score: 0.731059)
circHIPK3  (Score: 0.731059)
Slco3a1-206  (Score: 0.731059)
circHIPK3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transfection//ELISA//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35314952
Disease Name:Arthritis, Gouty
Sample:AGA patients and cell line
Dysfunction Pattern:Interaction(miR-2-3p)
Validated Method:qRT-PCR//Transfection//ELISA//Luciferase Report Assay
Description:Expressions of serum H19 in AGA patients were significantly higher than that in controls. The ROC curve indicated the potential of H19 as a diagnostic marker for AGA. Cell experiments revealed that the downregulation of H19 significantly inhibited the expressions of IL-1β, IL-8, and TNF-α. The luciferase reporter gene assay manifested that miR-22-3p is the target gene of H19. And knockdown of miR-22-3p overturned the downregulation of inflammatory factors caused by H19 inhibition. H19 aggravated MSU-induced THP-1 inflammation by negatively targeting miR-22-3p, suggesting a new regulatory mechanism and potential therapeutic target for AGA.
Causality:No
Causal Description:
Clinical-realted Application: