Entry Detail

General Information

Database ID: LDA0021541
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript
Category:LncRNA
Species:Mus musculus
Synonyms:EyeLinc6
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):142129267End Site(bp):142131883
External Links:
Ensembl ID:ENSMUSG00000000031
Ensembl Transcript ID:N/A
Entrez Gene:14955.0
NONCODE ID:N/A
RefSeq Accession:NR_130973.1

 

ncRNA Association Statistics

Total Associated Disease Number:214   
More Information
Causal Disease Number:122
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Glioma  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2986D005922
Disease Name:IgA glomerulonephritisGlomerulonephritis, IGA
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:A glomerulonephritis characterized by build up of IgA antibody in the glomerulus.A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE.
Alias:Berger's IgA or IgG nephropathy//Focal Glomerulonephritis//IgA nephropathy//primary IgA nephropathy//segmental glomerulonephritisGlomerulonephritis, IGA//Glomerulonephritides, IGA//Berger's Disease//Bergers Disease//IGA Glomerulonephritis//Nephropathy, IGA//Iga Nephropathy 1//Nephropathy 1, Iga//Immunoglobulin A Nephropathy//Nephropathy, Immunoglobulin A//Nephritis, IGA Type//IGA Type Nephritis//Berger Disease//IGA Nephropathy

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:qPCR
Weak Evidence:

 

Reference

[1] PubMed ID:36574208
Disease Name:Glomerulonephritis, IGA
Sample:204 patients with IgAN
Dysfunction Pattern:Expression(lower expressed)
Validated Method:qPCR
Description:H19 expression was significantly downregulated in patients with IgAN compared to healthy controls.
Causality:No
Causal Description:
Clinical-realted Application:Restricted cubic spline analyses showed that the relationship was negatively and linearly correlated (P for nonlinearly = 0.256). After adjusting for other potential clinical, pathologic, and treatment factors, H19 was found to be a protective factor for prognosis in IgAN (HR, 0.52; 95% CI 0.32-0.84; P = 0.008). ROC curve analysis showed that the clinical value of lncRNA H19 with CKD and area under the ROC curve was 0.746 (95% CI 0.663-0.829; P < 0.001) of the clinical prognostic value of H19.