Entry Detail

General Information

Database ID: LDA0021557
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTAIR
Full Name:HOX transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXAS|HOXC-AS4|HOXC11-AS1|NCRNA00072
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):53962308End Site(bp):53974956
External Links:
Ensembl ID:ENSG00000228630
Ensembl Transcript ID:N/A
Entrez Gene:100124700.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:110   
More Information
Causal Disease Number:68
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11946D000026
Disease Name:obsolete habitual abortionAbortion, Habitual
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:Three or more consecutive spontaneous abortions.
Alias:Aborter - recurrent//Habitual aborter//Habitual aborter - unspecified (disorder)//Habitual aborter NOS (disorder)//chronic spontaneous abortion//recurrent abortion (disorder)//recurrent miscarriageAbortion, Habitual//Habitual Abortion//Habitual Abortions//Abortion, Recurrent//Recurrent Abortion//Recurrent Abortions//Miscarriage, Recurrent//Recurrent Miscarriage//Recurrent Miscarriages//Recurrent Early Pregnancy Loss

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
lnc-CES1-1  (Score: 0.731059)
lnc-CES1-1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:36421813
Disease Name:Abortion, Habitual
Sample:HOTAIR gene
Dysfunction Pattern:Mutation(rs4759314 A>G, rs920778 T>C, rs1899663 G>T, and rs7958904 G>C)
Validated Method:Genotyping
Description:
Causality:No
Causal Description:
Clinical-realted Application: In all assays, p < 0.05 was considered significant. HOTAIR polymorphisms rs4759314A>G and rs920778T>C were highly associated with increased risk of RPL, specifically the haplotypes rs4759314A>G/rs1899663G>T (G-T) and rs4759314A>G/rs920778 T>C (G-C).