Entry Detail


General Information

Database ID: LDA0021558
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTAIR
Full Name:HOX transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXAS|HOXC-AS4|HOXC11-AS1|NCRNA00072
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):53962308End Site(bp):53974956
External Links:
Ensembl ID:ENSG00000228630
Ensembl Transcript ID:N/A
Entrez Gene:100124700.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:110   
More Information
Causal Disease Number:68
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:6713D020521
Disease Name:cerebrovascular diseaseStroke
Category:Disease OntologyMeSH
Type:Nervous System Diseases
Define:An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain.A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Alias:CVA//cerebrovascular disorder//strokeStroke//Strokes//Cerebrovascular Accident//Cerebrovascular Accidents//CVA (Cerebrovascular Accident)//CVAs (Cerebrovascular Accident)//Cerebrovascular Apoplexy//Apoplexy, Cerebrovascular//Vascular Accident, Brain//Brain Vascular Accident//Brain Vascular Accidents//Vascular Accidents, Brain//Cerebrovascular Stroke//Cerebrovascular Strokes//Stroke, Cerebrovascular//Strokes, Cerebrovascular//Apoplexy//Cerebral Stroke//Cerebral Strokes//Stroke, Cerebral//Strokes, Cerebral//Stroke, Acute//Acute Stroke//Acute Strokes//Strokes, Acute//Cerebrovascular Accident, Acute//Acute Cerebrovascular Accident//Acute Cerebrovascular Accidents//Cerebrovascular Accidents, Acute

 

Disease Association Statistics

Total Associated ncRNA Number:18   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:36439973
Disease Name:Stroke
Sample:serum of 181 CVS patients
Dysfunction Pattern:Expression(lower expressed)
Validated Method:qRT-PCR
Description:When compared to controls, lncHOTAIR was significantly downregulated in all case groups (medians in hypertensive and non-hypertensive patients were 0.13, and 0.34, respectively), with a significantly lower level in the hypertensive group (P = 0.05).
Causality:No
Causal Description:
Clinical-realted Application: