Entry Detail

General Information

Database ID: LDA0021567
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HNRNPU
Full Name:heterogeneous nuclear ribonucleoprotein U
Category:LncRNA
Species:Homo sapiens
Synonyms:DEE54|EIEE54|GRIP120|HNRNPU-AS1|HNRPU|SAF-A|SAFA|U21.1|hnRNP U|pp120
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):244850297End Site(bp):244864543
External Links:
Ensembl ID:ENSG00000153187
Ensembl Transcript ID:N/A
Entrez Gene:3192.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:418D012595
Disease Name:systemic sclerodermaScleroderma, Systemic
Category:Disease OntologyMeSH
Type:Skin and Connective Tissue Diseases
Define:A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Alias:Scleroderma//Scleroderma syndrome//progressive systemic sclerosis//systemic sclerosisScleroderma, Systemic//Systemic Sclerosis//Sclerosis, Systemic//Systemic Scleroderma

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30866419
Disease Name:Scleroderma, Systemic
Sample:SSc's peripheral blood mononuclear cells
Dysfunction Pattern:Expression[Expression[lower expressed]-expression]
Validated Method:qRT-PCR
Description:We profiled 542,500 transcripts in peripheral blood mononuclear cells (PBMCs) from 20 SSc patients and 20 healthy donors using Clariom D arrays, confirming the results by Reverse Transcription Polymerase-chain reaction (RT-PCR). A total of 837 coding-genes were modulated in SSc patients, whereas only one lncRNA, heterogeneous nuclear ribonucleoprotein U processed transcript (ncRNA00201), was significantly Expression[down-expression]regulated.
Causality:No
Causal Description:
Clinical-realted Application: