Entry Detail

General Information

Database ID: LDA0021593
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HECTD1
Full Name:HECT domain E3 ubiquitin protein ligase 1
Category:LncRNA
Species:Homo sapiens
Synonyms:EULIR
Chromosome:14
Strand:-
Coordinate:
Start Site(bp):31100117End Site(bp):31207793
External Links:
Ensembl ID:ENSG00000092148
Ensembl Transcript ID:N/A
Entrez Gene:25831.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000083242
Disease Name:Ischemic Stroke
Category:MeSH
Type:Nervous System Diseases
Define:Stroke due to BRAIN ISCHEMIA resulting in interruption or reduction of blood flow to a part of the brain. When obstruction is due to a BLOOD CLOT formed within in a cerebral blood vessel it is a thrombotic stroke. When obstruction is formed elsewhere and moved to block a cerebral blood vessel (see CEREBRAL EMBOLISM) it is referred to as embolic stroke. Wake-up stroke refers to ischemic stroke occurring during sleep while cryptogenic stroke refers to ischemic stroke of unknown origin.
Alias:Ischemic Stroke//Ischemic Strokes//Stroke, Ischemic//Ischaemic Stroke//Ischaemic Strokes//Stroke, Ischaemic//Cryptogenic Ischemic Stroke//Cryptogenic Ischemic Strokes//Ischemic Stroke, Cryptogenic//Stroke, Cryptogenic Ischemic//Cryptogenic Stroke//Cryptogenic Strokes//Stroke, Cryptogenic//Cryptogenic Embolism Stroke//Cryptogenic Embolism Strokes//Embolism Stroke, Cryptogenic//Stroke, Cryptogenic Embolism//Wake-up Stroke//Stroke, Wake-up//Wake up Stroke//Wake-up Strokes//Acute Ischemic Stroke//Acute Ischemic Strokes//Ischemic Stroke, Acute//Stroke, Acute Ischemic

 

Disease Association Statistics

Total Associated ncRNA Number:84   
More Information
Causal ncRNA Number:40
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.985791)
PVT1  (Score: 0.985791)
CASC15  (Score: 0.731059)
Pvt1  (Score: 0.731059)
SNHG15  (Score: 0.731059)
SERPINB9P1  (Score: 0.731059)
ADAMTS9-AS2  (Score: 0.731059)
Gm12610  (Score: 0.731059)
Cdc14a  (Score: 0.731059)
U90926  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31257675
Disease Name:Ischemic Stroke
Sample:peripheral blood
Dysfunction Pattern:Expression[Expression[Expression[highly expressed]-expression]-expression]
Validated Method:qRT-PCR
Description:CircRNA HECTD1 relative expression was higher in AIS patients (1.951 [1.078‐3.423]) than that in controls (0.886 [0.497‐1.296]) (P < 0.001; Figure ​Figure1A).1A).
Causality:No
Causal Description:
Clinical-realted Application:CircRNA HECTD1 expression was higher in AIS patients than that in controls, and the receiver operating characteristic (ROC) curve revealed that circRNA HECTD1 expression was of a good value in distinguishing AIS patients from controls with area under the curve (AUC) of 0.814 (95% CI: 0.768-0.859). In AIS patients, circRNA HECTD1 expression was positively correlated with NIHSS score, CRP, and pro-inflammatory cytokines. CircRNA HECTD1 expression was increased in AIS recurrence patients compared to non-recurrence patients, and further, ROC curve analysis disclosed that circRNA HECTD1 expression predicted higher risk of AIS recurrence (AUC: 0.694, 95% CI: 0.586-0.801). Additionally, circRNA HECTD1 expression was negatively correlated with RFS.