Entry Detail

General Information

Database ID: LDA0021654
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FER1L4
Full Name:fer-1 like family member 4 (pseudogene)
Category:LncRNA
Species:Homo sapiens
Synonyms:C20orf124
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):35558737End Site(bp):35607562
External Links:
Ensembl ID:ENSG00000088340
Ensembl Transcript ID:N/A
Entrez Gene:80307.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:32   
More Information
Causal Disease Number:22
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.959542)
Colorectal Neoplasms  (Score: 0.959542)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1380D016889
Disease Name:endometrial cancerEndometrial Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A uterine cancer that is located_in tissues lining the uterus.Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Alias:endometrial Ca//endometrial neoplasm//malignant endometrial neoplasm//malignant neoplasm of endometrium//neoplasm of endometrium//primary malignant neoplasm of endometrium//tumor of EndometriumEndometrial Neoplasms//Endometrial Neoplasm//Neoplasm, Endometrial//Neoplasms, Endometrial//Endometrial Carcinoma//Carcinoma, Endometrial//Carcinomas, Endometrial//Endometrial Carcinomas//Endometrial Cancer//Cancer, Endometrial//Cancers, Endometrial//Endometrial Cancers//Endometrium Cancer//Cancer, Endometrium//Cancers, Endometrium//Cancer of the Endometrium//Carcinoma of Endometrium//Endometrium Carcinoma//Endometrium Carcinomas//Cancer of Endometrium//Endometrium Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:232   
More Information
Causal ncRNA Number:178
Network:
Top Causal ncRNAs:
DLEU1  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
DLEU1  (Score: 0.999893)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001610  (Score: 0.985791)
hsa_circ_0075960  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30556848
Disease Name:Endometrial Neoplasms
Sample:EC tissues
Dysfunction Pattern:Expression[lower expressed]
Validated Method:qRT-PCR
Description:We observed that FER1L4 in EC tissues was significantly down-regulated compared with adjacent non-tumor tissues (p<0.01).
Causality:No
Causal Description:
Clinical-realted Application:Low expression of FER1L4 was significantly correlated with distant metastasis (p=0.002), lymph node metastasis (p=0.010) and FIGO stages (p=0.006). Furthermore, Kaplan-Meier survival curves showed that overall survival rate in patients with high FER1L4 expression level was markedly higher than those with low FER1L4 expression level (p=0.0071).