Entry Detail

General Information

Database ID: LDA0021671
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FOXD2-AS1
Full Name:FOXD2 adjacent opposite strand RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):47432133End Site(bp):47434641
External Links:
Ensembl ID:ENSG00000237424
Ensembl Transcript ID:N/A
Entrez Gene:84793.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:38
Network:
Top Causal Diseases:
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4074
Disease Name:pancreatic adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic carcinoma that derives_from epithelial cells of glandular origin.
Alias:pancreas adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
SNHG16  (Score: 0.731059)
CCHE1  (Score: 0.731059)
circMYBL2  (Score: 0.731059)
LINC01139  (Score: 0.731059)
LINC01857  (Score: 0.731059)
LINC00857  (Score: 0.731059)
lnc-IUR  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35377978
Disease Name:pancreatic adenocarcinoma
Sample:PAAD tissues and cells
Dysfunction Pattern:Interaction( PAAD cell and tissues)
Validated Method:qRT-PCR//Transwell Assay
Description: Analysis of the TCGA dataset revealed that FOXD2-AS1 was upregulated in PAAD tissues compared to the non-cancer tissues (1.89 vs. 0.2 TPM), indicating potential involvement of FOXD2-AS1 in PAAD. Our own data also showed FOXD2-AS1 was overexpressed in PAAD. It is predicted that miR-30a-3p can bind FOXD2-AS1, while their overexpression did not affect each other's expression. Correlation analysis revealed a significant correlation between FOXD2-AS1 and COX-2. In addition, FOXD2-AS1 overexpression increased COX-2 level, while miR-30a-3p played an opposite role. FOXD2-AS1 and COX-2 overexpression increased PAAD cell invasion and migration. MiR-30a-3p played an opposite role and inhibited the effects of FOXD2-AS1 and COX-2 overexpression.
Causality:No
Causal Description:
Clinical-realted Application: Moreover, high FOXD2-AS1 levels predicted poor survival.