Entry Detail

General Information

Database ID: LDA0021736
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FARP1
Full Name:FERM, ARH/RhoGEF and pleckstrin domain protein 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CDEP|FARP1-IT1|GLCC1|PLEKHC2|PPP1R75
Chromosome:13
Strand:+
Coordinate:
Start Site(bp):98142589End Site(bp):98455176
External Links:
Ensembl ID:ENSG00000152767
Ensembl Transcript ID:N/A
Entrez Gene:10160.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9256D015179
Disease Name:colorectal cancerColorectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A large intestine cancer that is located_in the colon and/or located_in the rectum.Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Alias:Colorectal Neoplasms//Colorectal Neoplasm//Neoplasm, Colorectal//Neoplasms, Colorectal//Colorectal Tumors//Colorectal Tumor//Tumor, Colorectal//Tumors, Colorectal//Colorectal Cancer//Cancer, Colorectal//Cancers, Colorectal//Colorectal Cancers//Colorectal Carcinoma//Carcinoma, Colorectal//Carcinomas, Colorectal//Colorectal Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:1274   
More Information
Causal ncRNA Number:984
Network:
Top Causal ncRNAs:
TP73-AS1  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
TUG1  (Score: 1)
ZFAS1  (Score: 1)
XIST  (Score: 1)
SNHG6  (Score: 1)
MEG3  (Score: 1)
HOTTIP  (Score: 1)
MCM3AP-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Northern Blot//Western Blot//ISH//Co-IP//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:31375671
Disease Name:Colorectal Neoplasms
Sample:cell lines
Dysfunction Pattern:Interaction[stabilizing c-Myc]
Validated Method:RNA Pull-Down//Northern Blot//Western Blot//ISH//Co-IP//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//ChIP
Description:In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under glucose starvation in CRC cells, supporting cell survival and proliferation by enhancing glycolysis. Mechanistically, GLCC1 stabilizes c-Myc transcriptional factor from ubiquitination by direct interaction with HSP90 chaperon and further specifies the transcriptional modification pattern on c-Myc target genes, such as LDHA, consequently reprogram glycolytic metabolism for CRC proliferation.
Causality:No
Causal Description:
Clinical-realted Application: Clinically, GLCC1 is associated with tumorigenesis, tumor size and predicts poor prognosis.