Entry Detail

General Information

Database ID: LDA0021779
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GHET1
Full Name:gastric carcinoma proliferation enhancing transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:lncRNA-GHET1
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):148987527End Site(bp):148989429
External Links:
Ensembl ID:ENSG00000281189
Ensembl Transcript ID:N/A
Entrez Gene:102723099.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Carcinoma, Renal Cell  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Head and Neck Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:30840282
Disease Name:Glioma
Sample:cell lines
Dysfunction Pattern:Interaction[down-regulation of miR-216a]
Validated Method:CCK8//qRT-PCR//Western Blot
Description:The viability, migration and invasion of U251 cells were promoted by GHET1 overexpression. The pro-cell cycle genes including Cyclin D1, CDK4 and CDK6, and the pro-metastasis genes including MMP-9 and Vimentin were up-regulated after GHET1 was overexpressed. MiR-216a was found to be down-regulated by GHET1 overexpression, and it was involved in the effects of GHET1 on U251 cells. GHET1 might promote U251 cells by down-regulating miR-216a. Finally, we found that GHET1 overexpression activated the JAK2/STAT3 and p53/survivin signaling pathways by down-regulating miR-216a.
Causality:No
Causal Description:
Clinical-realted Application: