Entry Detail

General Information

Database ID: LDA0021808
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FUNDC1
Full Name:FUN14 domain containing 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):44523639End Site(bp):44542859
External Links:
Ensembl ID:ENSG00000069509
Ensembl Transcript ID:N/A
Entrez Gene:139341.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000083242
Disease Name:Ischemic Stroke
Category:MeSH
Type:Nervous System Diseases
Define:Stroke due to BRAIN ISCHEMIA resulting in interruption or reduction of blood flow to a part of the brain. When obstruction is due to a BLOOD CLOT formed within in a cerebral blood vessel it is a thrombotic stroke. When obstruction is formed elsewhere and moved to block a cerebral blood vessel (see CEREBRAL EMBOLISM) it is referred to as embolic stroke. Wake-up stroke refers to ischemic stroke occurring during sleep while cryptogenic stroke refers to ischemic stroke of unknown origin.
Alias:Ischemic Stroke//Ischemic Strokes//Stroke, Ischemic//Ischaemic Stroke//Ischaemic Strokes//Stroke, Ischaemic//Cryptogenic Ischemic Stroke//Cryptogenic Ischemic Strokes//Ischemic Stroke, Cryptogenic//Stroke, Cryptogenic Ischemic//Cryptogenic Stroke//Cryptogenic Strokes//Stroke, Cryptogenic//Cryptogenic Embolism Stroke//Cryptogenic Embolism Strokes//Embolism Stroke, Cryptogenic//Stroke, Cryptogenic Embolism//Wake-up Stroke//Stroke, Wake-up//Wake up Stroke//Wake-up Strokes//Acute Ischemic Stroke//Acute Ischemic Strokes//Ischemic Stroke, Acute//Stroke, Acute Ischemic

 

Disease Association Statistics

Total Associated ncRNA Number:84   
More Information
Causal ncRNA Number:40
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.985791)
PVT1  (Score: 0.985791)
CASC15  (Score: 0.731059)
Pvt1  (Score: 0.731059)
SNHG15  (Score: 0.731059)
SERPINB9P1  (Score: 0.731059)
ADAMTS9-AS2  (Score: 0.731059)
Gm12610  (Score: 0.731059)
Cdc14a  (Score: 0.731059)
U90926  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:IP//qPCR//PCR
Weak Evidence:

 

Reference

[1] PubMed ID:35720103
Disease Name:Ischemic Stroke
Sample:peripheral blood
Dysfunction Pattern:Expression(highly expressed)
Validated Method:IP//qPCR//PCR
Description:Compared to the controls, the levels of three circRNAs were significantly increased in three subgroups of patients, including large artery atherosclerosis (LAA) stroke, small artery occlusion (SAO) stroke, and cardioembolism (CE) stroke (all P < 0.001).Among, LAA stroke patients had higher levels of circular RNA FUNDC1 (circFUNDC1) compared to SAO stroke patients (P = 0.015). CircFUNDC1 levels were positively correlated with National Institutes of Health Stroke Scale (NIHSS) scores on the 7th day only in LAA patients (P = 0.048, r = 0.226). It should be noted that the levels of circFUNDC1 in patients with early neurological deterioration (END), admitted within 24 h after onset, were significantly higher than those without END (P = 0.013). In addition, circFUNDC1 levels positively correlated with baseline NIHSS scores (P = 0.016, r = 0.203) or the 7th day NIHSS scores (P = 0.001, r = 0.289) in patients within 24 h after onset. Importantly, after 18 months of follow-up, a significant difference was observed on survival Kaplan-Meier curves (P = 0.042) between AIS patients with low (below cut-off) or high circFUNDC1 levels (above cut-off).
Causality:No
Causal Description:
Clinical-realted Application:Compared to the controls, the levels of three circRNAs were significantly increased in three subgroups of patients, including large artery atherosclerosis (LAA) stroke, small artery occlusion (SAO) stroke, and cardioembolism (CE) stroke (all P < 0.001).Among, LAA stroke patients had higher levels of circular RNA FUNDC1 (circFUNDC1) compared to SAO stroke patients (P = 0.015). CircFUNDC1 levels were positively correlated with National Institutes of Health Stroke Scale (NIHSS) scores on the 7th day only in LAA patients (P = 0.048, r = 0.226). It should be noted that the levels of circFUNDC1 in patients with early neurological deterioration (END), admitted within 24 h after onset, were significantly higher than those without END (P = 0.013). In addition, circFUNDC1 levels positively correlated with baseline NIHSS scores (P = 0.016, r = 0.203) or the 7th day NIHSS scores (P = 0.001, r = 0.289) in patients within 24 h after onset. Importantly, after 18 months of follow-up, a significant difference was observed on survival Kaplan-Meier curves (P = 0.042) between AIS patients with low (below cut-off) or high circFUNDC1 levels (above cut-off).