Entry Detail

General Information

Database ID: LDA0021826
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GAS5
Full Name:growth arrest specific 5
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00030|SNHG2
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):173863899End Site(bp):173868882
External Links:
Ensembl ID:ENSG00000234741
Ensembl Transcript ID:N/A
Entrez Gene:60674.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Glioma  (Score: 1)
Osteosarcoma  (Score: 1)
Arthritis, Rheumatoid  (Score: 1)
Osteosarcoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D011472
Disease Name:Prostatitis
Category:MeSH
Type:Urogenital Diseases
Define:Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment.
Alias:Prostatitis//Prostatitides//Chronic Prostatitis with Chronic Pelvic Pain Syndrome//Chronic Bacterial Prostatitis//Bacterial Prostatitides, Chronic//Bacterial Prostatitis, Chronic//Chronic Bacterial Prostatitides//Prostatitides, Chronic Bacterial//Acute Bacterial Prostatitis//Acute Bacterial Prostatitides//Bacterial Prostatitides, Acute//Bacterial Prostatitis, Acute//Asymptomatic Inflammatory Prostatitis//Asymptomatic Inflammatory Prostatitides//Inflammatory Prostatitis, Asymptomatic

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:RIP//MTT//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:30892130
Disease Name:Prostatitis
Sample:prostatitis tissues
Dysfunction Pattern:Interaction[COX-2 ]
Validated Method:RIP//MTT//Western Blot
Description:The expression of GAS5 was decreased, while COX-2 was increased in prostatitis tissues and in LPS-induced RWPE-1 cells. The overexpression of GAS5 suppressed the protein level of COX-2, and inhibited cell proliferation of LPS-induced RWPE-1 cells and HPECs, which was rescued by the co-transfection with pcDNA-GAS5 and pcDNA-COX-2. GAS5 was confirmed to promote the ubiquitination of COX-2, and the in vivo GAS5-overexpressed CNP rat model decreased the motor scores, the volume of prostate tissues, the average number of inflammatory cells, prostatic proliferation, and COX-2 expression.
Causality:No
Causal Description:
Clinical-realted Application: