Entry Detail

General Information

Database ID: LDA0021835
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GAS5
Full Name:growth arrest specific 5
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00030|SNHG2
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):173863899End Site(bp):173868882
External Links:
Ensembl ID:ENSG00000234741
Ensembl Transcript ID:N/A
Entrez Gene:60674.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Glioma  (Score: 1)
Osteosarcoma  (Score: 1)
Arthritis, Rheumatoid  (Score: 1)
Osteosarcoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:437D009157
Disease Name:myasthenia gravisMyasthenia Gravis
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath.A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.
Alias:Myasthenia Gravis//Myasthenia Gravis, Ocular//Ocular Myasthenia Gravis//Myasthenia Gravis, Generalized//Generalized Myasthenia Gravis//Muscle-Specific Receptor Tyrosine Kinase Myasthenia Gravis//Muscle Specific Receptor Tyrosine Kinase Myasthenia Gravis//Muscle-Specific Tyrosine Kinase Antibody Positive Myasthenia Gravis//Muscle Specific Tyrosine Kinase Antibody Positive Myasthenia Gravis//MuSK MG//MuSK Myasthenia Gravis//Myasthenia Gravis, MuSK//Anti-MuSK Myasthenia Gravis//Anti MuSK Myasthenia Gravis//Myasthenia Gravis, Anti-MuSK

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
LINC00680  (Score: 0.731059)
circFBL  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
LINC00680  (Score: 0.731059)
circFBL  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transfection//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:34936242
Disease Name:Myasthenia Gravis
Sample:peripheral blood mononuclear cells
Dysfunction Pattern:Regulation( IL-10)
Validated Method:qRT-PCR//Transfection//Western Blot
Description:GAS5 and IL-10 mRNA levels in peripheral blood mononuclear cells (PBMCs) were significantly lower in MG patients than healthy controls.
Causality:No
Causal Description:
Clinical-realted Application:Downregulated GAS5 effectively distinguished MG patients from healthy controls. GAS5 expression was positively correlated with IL-10 expression in both MG patients and healthy controls. GAS5 overexpression significantly upregulated IL-10 expression in PBMCs derived from both MG patients and healthy controls.