Entry Detail

General Information

Database ID: LDA0021852
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ADGRG3
Full Name:adhesion G protein-coupled receptor G3
Category:LncRNA
Species:Homo sapiens
Synonyms:GPR97|PB99|PGR26
Chromosome:16
Strand:+
Coordinate:
Start Site(bp):57665629End Site(bp):57689378
External Links:
Ensembl ID:ENSG00000182885
Ensembl Transcript ID:N/A
Entrez Gene:222487.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10325D012829
Disease Name:silicosisSilicosis
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.
Alias:Pneumoconiosis due to silicates//Silica pneumoconiosis//Silicotic fibrosis of lung//silicotuberculosisSilicosis//Silicoses

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
Snhg20  (Score: 0.731059)
hsa_circ_0058493  (Score: 0.731059)
XIST  (Score: 0.731059)
MRAK050699  (Score: 0.731059)
Snhg20  (Score: 0.731059)
hsa_circ_0058493  (Score: 0.731059)
XIST  (Score: 0.731059)
MRAK050699  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:35289324
Disease Name:Silicosis
Sample:blood lymphocytes of eight participants
Dysfunction Pattern:Mutation(rs1814521)
Validated Method:RNA-seq//Genotyping
Description:The presence of the SNP rs1814521 in the lncRNA ADGRG3 is associated with susceptibility to silicosis. Furthermore, five SNPs were found to be significantly correlated with the risk of silicosis by GWAS screening (P < 0.05), while the results of GWAS and iMLDR validation indicated that the variant A allele of rs1814521 was associated with a reduced risk of silicosis (OR = 0.76, 95% CI = 0.62-0.94, P = 0.011).
Causality:No
Causal Description:
Clinical-realted Application: