Entry Detail


General Information

Database ID: LDA0021862
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ADAMTS9-AS1
Full Name:ADAMTS9 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):64561346End Site(bp):64590084
External Links:
Ensembl ID:ENSG00000241158
Ensembl Transcript ID:N/A
Entrez Gene:101929335.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Glioma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Glioma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Endometriosis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11984D002312
Disease Name:hypertrophic cardiomyopathyCardiomyopathy, Hypertrophic
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
Alias:hypertrophic obstructive cardiomyopathyCardiomyopathy, Hypertrophic//Cardiomyopathies, Hypertrophic//Hypertrophic Cardiomyopathies//Hypertrophic Cardiomyopathy//Cardiomyopathy, Hypertrophic Obstructive//Cardiomyopathies, Hypertrophic Obstructive//Hypertrophic Obstructive Cardiomyopathies//Hypertrophic Obstructive Cardiomyopathy//Obstructive Cardiomyopathies, Hypertrophic//Obstructive Cardiomyopathy, Hypertrophic

 

Disease Association Statistics

Total Associated ncRNA Number:10   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RIP//FISH
Weak Evidence:

 

Reference

[1] PubMed ID:35401927
Disease Name:Cardiomyopathy, Hypertrophic
Sample:peripheral blood samples from HCM patients
Dysfunction Pattern:Interaction(ADAMTS9-AS1/circFN1-miR-206-ACTB regulatory network)
Validated Method:qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray
Description:ADAMTS9-AS1, circFN1, and ACTB were found to be poorly expressed, and miR-206 was highly expressed in HCM. In vitro experimentation further confirmed that ADAMTS9-AS1 and circFN1 could competitively bind to miR-206, thereby augmenting ACTB expression.
Causality:No
Causal Description:
Clinical-realted Application: