Entry Detail

General Information

Database ID: LDA0022006
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ATG5
Full Name:autophagy related 5
Category:LncRNA
Species:Homo sapiens
Synonyms:APG5|APG5-LIKE|APG5L|ASP|SCAR25|hAPG5
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):106184476End Site(bp):106325760
External Links:
Ensembl ID:ENSG00000057663
Ensembl Transcript ID:N/A
Entrez Gene:9474.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077277
Disease Name:Esophageal Squamous Cell Carcinoma
Category:MeSH
Type:Neoplasms
Define:A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.
Alias:Esophageal Squamous Cell Carcinoma//Oesophageal Squamous Cell Carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:2730   
More Information
Causal ncRNA Number:360
Network:
Top Causal ncRNAs:
ciRS-7  (Score: 1)
ZNF667-AS1  (Score: 1)
SNHG6  (Score: 1)
ZNF667-AS1  (Score: 1)
BBOX1-AS1  (Score: 1)
SNHG6  (Score: 1)
CASC9  (Score: 1)
ciRS-7  (Score: 1)
CASC9  (Score: 1)
BBOX1-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:29604464
Disease Name:Esophageal Squamous Cell Carcinoma
Sample:cancer tissues
Dysfunction Pattern:Expression [highly expressed]
Validated Method:qRT-PCR//RNA-seq
Description:We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR.
Causality:No
Causal Description:
Clinical-realted Application: