Entry Detail

General Information

Database ID: LDA0022411
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CDKN2B-AS1
Full Name:CDKN2B antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS
Chromosome:9
Strand:+
Coordinate:
Start Site(bp):21994791End Site(bp):22121097
External Links:
Ensembl ID:ENSG00000240498
Ensembl Transcript ID:N/A
Entrez Gene:100048912.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:54
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
Glioma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Glioma  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8577D003093
Disease Name:ulcerative colitisColitis, Ulcerative
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
Alias:Left-sided ulcerative colitisColitis, Ulcerative//Idiopathic Proctocolitis//Ulcerative Colitis//Colitis Gravis//Inflammatory Bowel Disease, Ulcerative Colitis Type

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
H19  (Score: 0.985791)
H19  (Score: 0.985791)
hsa_circ_0001187  (Score: 0.731059)
Tug1  (Score: 0.731059)
SNHG5  (Score: 0.731059)
NORAD  (Score: 0.731059)
Meg3  (Score: 0.731059)
MEG3  (Score: 0.731059)
hsa_circ_0001187  (Score: 0.731059)
Tug1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31207308
Disease Name:Colitis, Ulcerative
Sample:colonic biopsy tissue
Dysfunction Pattern:Expression[lower expressed]
Validated Method:qRT-PCR//Western Blot
Description:One of the most significantly decreased genes on the array was CDKN2B-AS1 with a 12.2-fold Expression[down-expression]regulation and p = 0.00087 (Fig. 1a). This result is similar to that reported by others that have shown that CDKN2B-AS1 is significantly Expression[down-expression]-regulated in both ulcerative colitis and Crohn’s disease patients [7,12,13].
Causality:No
Causal Description:
Clinical-realted Application: