Entry Detail


General Information

Database ID: LDA0022413
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CDKN2B-AS1
Full Name:CDKN2B antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS
Chromosome:9
Strand:+
Coordinate:
Start Site(bp):21994791End Site(bp):22121097
External Links:
Ensembl ID:ENSG00000240498
Ensembl Transcript ID:N/A
Entrez Gene:100048912.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:54
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
Glioma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Glioma  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1686D005901
Disease Name:glaucomaGlaucoma
Category:Disease OntologyMeSH
Type:Eye Diseases
Define:An eye disease that is characterized by an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function.An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Alias:Glaucoma//Glaucomas

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:32010306
Disease Name:Glaucoma
Sample:blood
Dysfunction Pattern:Expression[lower expressed]
Validated Method:qRT-PCR
Description:Compared with those in the control group, patients in the study group had significantly lower expression of serum lncRNA MALAT1 and lncRNA ANRIL (P<0.05), significantly lower expression of serum PEDF and IL-12 (P<0.05), and significantly higher expression of serum Hcy and IL-4 (P<0.05), without significant difference in the expression of serum IFN-γ between the two groups (P>0.05).
Causality:No
Causal Description:
Clinical-realted Application:

[2] PubMed ID:35028972
Disease Name:Glaucoma
Sample:Three hundred and forty-six glaucoma patients and 263 healthy controls
Dysfunction Pattern:Mutation(rs2383207, rs564398, rs2157719, rs7865618, rs4977574 )
Validated Method:Genotyping
Description:
Causality:No
Causal Description:
Clinical-realted Application: