Entry Detail

General Information

Database ID: LDA0022418
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CHL1
Full Name:N/A
Category:LncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:N/A
NONCODE ID:N/A
RefSeq Accession:NR_045572.2

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3948D018268
Disease Name:adrenocortical carcinomaAdrenocortical Carcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Alias:Adrenal cortical carcinoma//carcinoma of the Adrenal cortexAdrenocortical Carcinoma//Adrenocortical Carcinomas//Carcinomas, Adrenocortical//Carcinoma, Adrenocortical//Carcinoma, Adrenal Cortical//Adrenal Cortical Carcinoma//Adrenal Cortical Carcinomas//Carcinomas, Adrenal Cortical

 

Disease Association Statistics

Total Associated ncRNA Number:30   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
ASB16-AS1  (Score: 0.731059)
circCCAC1  (Score: 0.731059)
H19  (Score: 0.731059)
ASB16-AS1  (Score: 0.731059)
circCCAC1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31522749
Disease Name:Adrenocortical Carcinoma
Sample:ACC tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//Microarray
Description: In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2.
Causality:No
Causal Description:
Clinical-realted Application: