Entry Detail

General Information

Database ID: LDA0022624
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CAHM
Full Name:colon adenocarcinoma hypermethylated
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00468
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):163413065End Site(bp):163413950
External Links:
Ensembl ID:ENSG00000270419
Ensembl Transcript ID:N/A
Entrez Gene:100526820.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Intervertebral Disc Degeneration  (Score: 0.731059)
Intervertebral Disc Degeneration  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Migration Assay//qRT-PCR//MTT//Invasion Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34227028
Disease Name:Glioma
Sample:glioma cells
Dysfunction Pattern:Regulation(SPAK/JNK Pathway)
Validated Method:Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//MTT//Invasion Assay//IF
Description: In glioma cells, CAHM is hypermethylated by DNA methyltransferase1 (DNMT1) and the loss of CAHM expression could be reversed by 5-Aza-2'-deoxycytidine (5-Aza), a specific inhibitor of DNA methyltransferases. Besides, the expression of CAHM was negatively associated with overall survival in both primary and recurrent gliomas. Overexpression of CAHM inhibited glioma cell proliferation, clone formation, and invasion. Further exploring results showed that CAHM overexpression suppressed glioma migration and invasion through SPAK/MAPK pathway.
Causality:No
Causal Description:
Clinical-realted Application:We found that CAHM expression was correlated with glioma grades, molecular subtype, IDH mutation status, and 1q/19p codel status.