Entry Detail

General Information

Database ID: LDA0022713
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CCAT2
Full Name:colon cancer associated transcript 2
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00873|NCCP1
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127400399End Site(bp):127402150
External Links:
Ensembl ID:ENSG00000280997
Ensembl Transcript ID:N/A
Entrez Gene:101805488.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:32   
More Information
Causal Disease Number:22
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Glioma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Glioma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11946D000026
Disease Name:obsolete habitual abortionAbortion, Habitual
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:Three or more consecutive spontaneous abortions.
Alias:Aborter - recurrent//Habitual aborter//Habitual aborter - unspecified (disorder)//Habitual aborter NOS (disorder)//chronic spontaneous abortion//recurrent abortion (disorder)//recurrent miscarriageAbortion, Habitual//Habitual Abortion//Habitual Abortions//Abortion, Recurrent//Recurrent Abortion//Recurrent Abortions//Miscarriage, Recurrent//Recurrent Miscarriage//Recurrent Miscarriages//Recurrent Early Pregnancy Loss

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
lnc-CES1-1  (Score: 0.731059)
lnc-CES1-1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:30982978
Disease Name:Abortion, Habitual
Sample:blood
Dysfunction Pattern:Mutation[rs6983267G ]
Validated Method:qRT-PCR//Genotyping
Description:We genotyped two lncRNA CCAT2 polymorphisms (rs6983267 and rs3843549) in 248 patients with recurrent miscarriage and 392 controls through a TaqMan real-time polymerase chain reaction assay, and the strength of each association was evaluated via 95% confidence intervals (CIs) and odds ratios (ORs). Our results showed that the rs6983267 G allele in lncRNA CCAT2 was associated with decreased susceptibility to recurrent miscarriage (TG vs. TT: adjusted OR = 0.603; 95% CI = 0.420-0.866; p = 0.0062; GG/TG vs. TT: adjusted OR = 0.620; 95% CI = 0.441-0.873; p = 0.0061). The combined analysis of the two protective polymorphisms (rs3843549 AA and rs6983267 TG/GG) revealed that individuals with two unfavorable alleles exhibited a lower risk of recurrent miscarriage than those with no or only one unfavorable allele (adjusted OR = 0.531; 95% CI = 0.382-0.739). Moreover, the decreased risk associated with the two protective alleles was most obvious in women aged less than 35 years (OR = 0.551; 95% CI = 0.378-0.8803; p = 0.0019) and in women with two to three miscarriages (adjusted OR = 0.466; 95% CI = 0.318-0.683; p < 0.0001). In conclusion, our study indicates that the rs6983267G allele might contribute to a decreased risk of recurrent miscarriage in the South Chinese population.
Causality:No
Causal Description:
Clinical-realted Application: