Entry Detail


General Information

Database ID: LDA0022721
Species: Homo sapiens
Confidence Score: 0.959542
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CDKN2B-AS1
Full Name:CDKN2B antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS
Chromosome:9
Strand:+
Coordinate:
Start Site(bp):21994791End Site(bp):22121097
External Links:
Ensembl ID:ENSG00000240498
Ensembl Transcript ID:N/A
Entrez Gene:100048912.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:54
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
Glioma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Glioma  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3393D003327
Disease Name:coronary artery diseaseCoronary Disease
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Alias:CHD//Coronary disease//coronary arteriosclerosis//coronary heart diseaseCoronary Disease//Coronary Diseases//Disease, Coronary//Diseases, Coronary//Coronary Heart Disease//Coronary Heart Diseases//Disease, Coronary Heart//Diseases, Coronary Heart//Heart Disease, Coronary//Heart Diseases, Coronary

 

Disease Association Statistics

Total Associated ncRNA Number:44   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
EZR-AS1  (Score: 0.731059)
LOXL1-AS1  (Score: 0.731059)
SENCR  (Score: 0.731059)
circCHFR  (Score: 0.731059)
THRIL  (Score: 0.731059)
EZR-AS1  (Score: 0.731059)
LOXL1-AS1  (Score: 0.731059)
SENCR  (Score: 0.731059)
circCHFR  (Score: 0.731059)
THRIL  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:Bioinformatics Analysis

 

Reference

[1] PubMed ID:31957852
Disease Name:Coronary Disease
Sample:patients with coronary heart disease
Dysfunction Pattern:Expression[lower expressed]
Validated Method:qRT-PCR
Description: The expression of LncRNA-ANRIL in patients with coronary heart disease was lower than that of normal subjects (p<0.05), and the expression levels of Gensini score, LDH, CK-MB, CK, and BNP gradually increased with the increased number of their diseased vessels (p<0.05).
Causality:No
Causal Description:
Clinical-realted Application:

[2] PubMed ID:34901274
Disease Name:Coronary Disease
Sample:112 patients with CHD
Dysfunction Pattern:Expression(lower expressed)
Validated Method:Bioinformatics Analysis
Description:The expression level of serum ANRIL in preSG was significantly lower than those in CG and postSG (P < 0.05).
Causality:No
Causal Description:
Clinical-realted Application: According to the survival curves, the 3-year overall survival rate in the high-ANRIL expression group was significantly lower than that in the low-expression group (P < 0.05).