Entry Detail

General Information

Database ID: LDA0022755
Species: Homo sapiens
Confidence Score: 0.548294
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC15
Full Name:cancer susceptibility 15
Category:LncRNA
Species:Homo sapiens
Synonyms:CANT|LINC00340|lnc-SOX4-1
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):21666413End Site(bp):22195820
External Links:
Ensembl ID:ENSG00000272168
Ensembl Transcript ID:N/A
Entrez Gene:401237.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:34   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.985791)
tongue squamous cell carcinoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
tongue squamous cell carcinoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9119D015470
Disease Name:acute myeloid leukemiaLeukemia, Myeloid, Acute
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Alias:AML - acute Myeloid Leukemia//Leukemia, Myelocytic, acute//acute myeloblastic leukaemia//acute myeloblastic leukemia//acute myelogenous leukaemia//acute myelogenous leukemia//acute myeloid leukaemiaLeukemia, Myeloid, Acute//Acute Myeloid Leukemia//Acute Myeloid Leukemias//Leukemias, Acute Myeloid//Myeloid Leukemias, Acute//ANLL//Leukemia, Acute Myelogenous//Leukemia, Acute Myeloid//Leukemia, Myeloblastic, Acute//Leukemia, Myelocytic, Acute//Leukemia, Myelogenous, Acute//Leukemia, Nonlymphoblastic, Acute//Leukemia, Nonlymphocytic, Acute//Myeloblastic Leukemia, Acute//Acute Myeloblastic Leukemia//Acute Myeloblastic Leukemias//Leukemia, Acute Myeloblastic//Leukemias, Acute Myeloblastic//Myeloblastic Leukemias, Acute//Myelocytic Leukemia, Acute//Acute Myelocytic Leukemia//Acute Myelocytic Leukemias//Leukemia, Acute Myelocytic//Leukemias, Acute Myelocytic//Myelocytic Leukemias, Acute//Myelogenous Leukemia, Acute//Myeloid Leukemia, Acute//Nonlymphoblastic Leukemia, Acute//Acute Nonlymphoblastic Leukemia//Acute Nonlymphoblastic Leukemias//Leukemia, Acute Nonlymphoblastic//Leukemias, Acute Nonlymphoblastic//Nonlymphoblastic Leukemias, Acute//Nonlymphocytic Leukemia, Acute//Acute Nonlymphocytic Leukemia//Acute Nonlymphocytic Leukemias//Leukemia, Acute Nonlymphocytic//Leukemias, Acute Nonlymphocytic//Nonlymphocytic Leukemias, Acute//Acute Myelogenous Leukemia//Acute Myelogenous Leukemias//Leukemias, Acute Myelogenous//Myelogenous Leukemias, Acute//Myeloid Leukemia, Acute, M1//Leukemia, Myeloid, Acute, M1//Acute Myeloid Leukemia without Maturation//Leukemia, Myeloid, Acute, M2//Myeloid Leukemia, Acute, M2//Acute Myeloid Leukemia with Maturation

 

Disease Association Statistics

Total Associated ncRNA Number:196   
More Information
Causal ncRNA Number:138
Network:
Top Causal ncRNAs:
SNHG1  (Score: 1)
SNHG1  (Score: 1)
NEAT1  (Score: 1)
NEAT1  (Score: 1)
TUG1  (Score: 0.999998)
TUG1  (Score: 0.999998)
MVIH  (Score: 0.999893)
SNHG5  (Score: 0.999893)
CDKN2B-AS1  (Score: 0.999893)
SNHG5  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:
Weak Evidence:Bioinformatics Analysis

 

Reference

[1] PubMed ID:35680788
Disease Name:Leukemia, Myeloid, Acute
Sample:BM cells
Dysfunction Pattern:Expression(lower expressed)
Validated Method:Bioinformatics Analysis
Description:The expression level of CASC15 was significantly decreased in BM cells of AML patients compared with healthy donors (P<0.001). The expression of CASC15 is decreased in AML, and low CASC15 expression may predict adverse prognosis in AML patients with NPM1 mutations.
Causality:No
Causal Description:
Clinical-realted Application: The expression of CASC15 was high at the early stage of hematopoiesis, and reached a peak at the stage of multipotent progenitors differentiation, then decreased rapidly, and was at a range of low level fluctuations in the subsequent process.