Entry Detail

General Information

Database ID: LDA0022756
Species: Homo sapiens
Confidence Score: 0.548294
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC15
Full Name:cancer susceptibility 15
Category:LncRNA
Species:Homo sapiens
Synonyms:CANT|LINC00340|lnc-SOX4-1
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):21666413End Site(bp):22195820
External Links:
Ensembl ID:ENSG00000272168
Ensembl Transcript ID:N/A
Entrez Gene:401237.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:34   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.985791)
tongue squamous cell carcinoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
tongue squamous cell carcinoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:769D009447
Disease Name:neuroblastomaNeuroblastoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An autonomic nervous system neoplasm that derives_from immature nerve cells.A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Alias:Neuroblastoma//Neuroblastomas

 

Disease Association Statistics

Total Associated ncRNA Number:98   
More Information
Causal ncRNA Number:60
Network:
Top Causal ncRNAs:
SNHG16  (Score: 1)
SNHG16  (Score: 1)
DUXAP9  (Score: 0.999893)
DLX6-AS1  (Score: 0.999893)
DLX6-AS1  (Score: 0.999893)
DUXAP9  (Score: 0.999893)
LINC00839  (Score: 0.985791)
SNHG7  (Score: 0.985791)
SNHG7  (Score: 0.985791)
LINC00839  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:
Weak Evidence:ChIP-seq//RNA-seq

 

Reference

[1] PubMed ID:31920530
Disease Name:Neuroblastoma
Sample:Neuroblastoma tissues
Dysfunction Pattern:Expression[Expression[highly expressed]-expression]
Validated Method:ChIP-seq//RNA-seq
Description:Differential analysis revealed nine significantly differentially expressed (more than 2-fold change with corrected p-value) lncRNAs between tumor cells and matched MNCs. Of these, RFPL1S (p = 0.0001), PPP1R26-AS1 (p = 0.03), RP11-439E19.3 (p = 1.24 × 10–6), CASC15 (p = 1.6 × 10–7), AC004540.5 (p = 0.0002), and CTD-2881E23.2 (p = 1.6 × 10–9) were found to be significantly Expression[up-expression]regulated (Figure 1B), while USP3-AS1 (p = 1.78 × 10–6), CHRM3-AS2 (p = 0.003) and RP6-99M1.2 (p = 0.002) were significantly downregulated (Figure 1C).
Causality:No
Causal Description:
Clinical-realted Application: