Entry Detail

General Information

Database ID: LDA0022761
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC11
Full Name:cancer susceptibility 11
Category:LncRNA
Species:Homo sapiens
Synonyms:CARLO7|CARLo-7|LINC00990|MYMLR|TCONS_00014535
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):127700608End Site(bp):127733967
External Links:
Ensembl ID:ENSG00000249375
Ensembl Transcript ID:N/A
Entrez Gene:100270680.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:34   
More Information
Causal Disease Number:26
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.731059)
esophageal carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3393D003327
Disease Name:coronary artery diseaseCoronary Disease
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Alias:CHD//Coronary disease//coronary arteriosclerosis//coronary heart diseaseCoronary Disease//Coronary Diseases//Disease, Coronary//Diseases, Coronary//Coronary Heart Disease//Coronary Heart Diseases//Disease, Coronary Heart//Diseases, Coronary Heart//Heart Disease, Coronary//Heart Diseases, Coronary

 

Disease Association Statistics

Total Associated ncRNA Number:44   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
EZR-AS1  (Score: 0.731059)
LOXL1-AS1  (Score: 0.731059)
SENCR  (Score: 0.731059)
circCHFR  (Score: 0.731059)
THRIL  (Score: 0.731059)
EZR-AS1  (Score: 0.731059)
LOXL1-AS1  (Score: 0.731059)
SENCR  (Score: 0.731059)
circCHFR  (Score: 0.731059)
THRIL  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:34001726
Disease Name:Coronary Disease
Sample:464 CHD patients and 510 healthy controls
Dysfunction Pattern:Mutation(rs9642880)
Validated Method:Genotyping
Description: The study displayed the contribution of CASC8, CASC11, and PVT1 genetic polymorphisms to CHD predisposition, and these variants could serve as potential biomarkers of CHD susceptibility.CASC11 rs9642880 (OR = 1.49, P = 0.021) was a risk factor for increased CHD susceptibility in subjects over 60 years old, and PVT1 rs4410871 was a protective factor for CHD susceptibility in males (OR = 0.67, P = 0.015) and smokers (OR = 0.62, P = 0.047).
Causality:No
Causal Description:
Clinical-realted Application: