Entry Detail

General Information

Database ID: LDA0022765
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CCAT1
Full Name:colon cancer associated transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CARLO5|CARLo-5|onco-lncRNA-40
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):127207382End Site(bp):127219268
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:100507056.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:46   
More Information
Causal Disease Number:30
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Adenocarcinoma of Lung  (Score: 0.999893)
Adenocarcinoma of Lung  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9119D015470
Disease Name:acute myeloid leukemiaLeukemia, Myeloid, Acute
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Alias:AML - acute Myeloid Leukemia//Leukemia, Myelocytic, acute//acute myeloblastic leukaemia//acute myeloblastic leukemia//acute myelogenous leukaemia//acute myelogenous leukemia//acute myeloid leukaemiaLeukemia, Myeloid, Acute//Acute Myeloid Leukemia//Acute Myeloid Leukemias//Leukemias, Acute Myeloid//Myeloid Leukemias, Acute//ANLL//Leukemia, Acute Myelogenous//Leukemia, Acute Myeloid//Leukemia, Myeloblastic, Acute//Leukemia, Myelocytic, Acute//Leukemia, Myelogenous, Acute//Leukemia, Nonlymphoblastic, Acute//Leukemia, Nonlymphocytic, Acute//Myeloblastic Leukemia, Acute//Acute Myeloblastic Leukemia//Acute Myeloblastic Leukemias//Leukemia, Acute Myeloblastic//Leukemias, Acute Myeloblastic//Myeloblastic Leukemias, Acute//Myelocytic Leukemia, Acute//Acute Myelocytic Leukemia//Acute Myelocytic Leukemias//Leukemia, Acute Myelocytic//Leukemias, Acute Myelocytic//Myelocytic Leukemias, Acute//Myelogenous Leukemia, Acute//Myeloid Leukemia, Acute//Nonlymphoblastic Leukemia, Acute//Acute Nonlymphoblastic Leukemia//Acute Nonlymphoblastic Leukemias//Leukemia, Acute Nonlymphoblastic//Leukemias, Acute Nonlymphoblastic//Nonlymphoblastic Leukemias, Acute//Nonlymphocytic Leukemia, Acute//Acute Nonlymphocytic Leukemia//Acute Nonlymphocytic Leukemias//Leukemia, Acute Nonlymphocytic//Leukemias, Acute Nonlymphocytic//Nonlymphocytic Leukemias, Acute//Acute Myelogenous Leukemia//Acute Myelogenous Leukemias//Leukemias, Acute Myelogenous//Myelogenous Leukemias, Acute//Myeloid Leukemia, Acute, M1//Leukemia, Myeloid, Acute, M1//Acute Myeloid Leukemia without Maturation//Leukemia, Myeloid, Acute, M2//Myeloid Leukemia, Acute, M2//Acute Myeloid Leukemia with Maturation

 

Disease Association Statistics

Total Associated ncRNA Number:196   
More Information
Causal ncRNA Number:138
Network:
Top Causal ncRNAs:
SNHG1  (Score: 1)
SNHG1  (Score: 1)
NEAT1  (Score: 1)
NEAT1  (Score: 1)
TUG1  (Score: 0.999998)
TUG1  (Score: 0.999998)
MVIH  (Score: 0.999893)
SNHG5  (Score: 0.999893)
CDKN2B-AS1  (Score: 0.999893)
SNHG5  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30943439
Disease Name:Leukemia, Myeloid, Acute
Sample:blood
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:We investigated the expression levels of LncRNAs in 70 patients; 30 with t(8;21) positive AML and 40 with t(8;21) negative AML, We found that CCAT1 and PVT1 are expressed in higher levels in t(8;21) positive -AML by 5.3 folds compared to t(8;21) negative group; the expression values were significantly associated with high-risk clinical criteria; moreover, they are associated with lower overall survival (OS) rate and leukemia-free survival (LFS), however we didn't find a statistically significant cut-off value of LncRNAs using the Cox regression analysis for Lnc_PVT1 except with LFS, we conclude that high expression levels of CCAT1 and PVT1 are associated with poor prognosis while being poor prognostic biomarkers in t(8;21) associated AML.
Causality:No
Causal Description:
Clinical-realted Application:We investigated the expression levels of LncRNAs in 70 patients; 30 with t(8;21) positive AML and 40 with t(8;21) negative AML, We found that CCAT1 and PVT1 are expressed in higher levels in t(8;21) positive -AML by 5.3 folds compared to t(8;21) negative group; the expression values were significantly associated with high-risk clinical criteria; moreover, they are associated with lower overall survival (OS) rate and leukemia-free survival (LFS), however we didn't find a statistically significant cut-off value of LncRNAs using the Cox regression analysis for Lnc_PVT1 except with LFS, we conclude that high expression levels of CCAT1 and PVT1 are associated with poor prognosis while being poor prognostic biomarkers in t(8;21) associated AML.