Entry Detail

General Information

Database ID: LDA0022782
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC8
Full Name:cancer susceptibility 8
Category:LncRNA
Species:Homo sapiens
Synonyms:CARLO1|CARLo-1|LINC00860
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):127289676End Site(bp):127482139
External Links:
Ensembl ID:ENSG00000246228
Ensembl Transcript ID:N/A
Entrez Gene:727677.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3393D003327
Disease Name:coronary artery diseaseCoronary Disease
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Alias:CHD//Coronary disease//coronary arteriosclerosis//coronary heart diseaseCoronary Disease//Coronary Diseases//Disease, Coronary//Diseases, Coronary//Coronary Heart Disease//Coronary Heart Diseases//Disease, Coronary Heart//Diseases, Coronary Heart//Heart Disease, Coronary//Heart Diseases, Coronary

 

Disease Association Statistics

Total Associated ncRNA Number:44   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
EZR-AS1  (Score: 0.731059)
LOXL1-AS1  (Score: 0.731059)
SENCR  (Score: 0.731059)
circCHFR  (Score: 0.731059)
THRIL  (Score: 0.731059)
EZR-AS1  (Score: 0.731059)
LOXL1-AS1  (Score: 0.731059)
SENCR  (Score: 0.731059)
circCHFR  (Score: 0.731059)
THRIL  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:34001726
Disease Name:Coronary Disease
Sample:464 CHD patients and 510 healthy controls
Dysfunction Pattern:Regulation
Validated Method:Genotyping
Description: The study displayed the contribution of CASC8, CASC11, and PVT1 genetic polymorphisms to CHD predisposition, and these variants could serve as potential biomarkers of CHD susceptibility.Complications (hypertension or diabetes) of CHD influenced the association between CASC8, CASC11, and PVT1 genetic polymorphisms and CHD predisposition. Moreover, CASC8, CASC11, and PVT1 polymorphisms were related to the number of pathological branches and Gensini score in CHD patients.
Causality:No
Causal Description:
Clinical-realted Application: