Entry Detail

General Information

Database ID: LDA0022783
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC8
Full Name:cancer susceptibility 8
Category:LncRNA
Species:Homo sapiens
Synonyms:CARLO1|CARLo-1|LINC00860
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):127289676End Site(bp):127482139
External Links:
Ensembl ID:ENSG00000246228
Ensembl Transcript ID:N/A
Entrez Gene:727677.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:399D014376
Disease Name:tuberculosisTuberculosis
Category:Disease OntologyMeSH
Type:Infections
Define:A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.
Alias:Tuberculosis//Tuberculoses//Kochs Disease//Koch's Disease//Koch Disease//Mycobacterium tuberculosis Infection//Infection, Mycobacterium tuberculosis//Infections, Mycobacterium tuberculosis//Mycobacterium tuberculosis Infections

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:32034808
Disease Name:Tuberculosis
Sample:
Dysfunction Pattern:Mutation[rs7836840 ]
Validated Method:Genotyping
Description: The lncRNA CASC8 genetic variant rs7836840 was associated with an increased tuberculosis risk with a P-value of .034, but .134 after Bonferroni correction. Using subtype analysis, the C allele in rs7836840 showed a significant association with tuberculosis susceptibility (OR = 1.196, 95% CI = 1.05-1.362, P = .02739 after Bonferroni correction). Patients carrying genotype AG and GG of rs7825118 and rs9297758 exhibited lower Hb concentrations (P = .006) and neutrophil counts (P = .015), respectively, while genotype AG and AA in rs6981424 demonstrated higher levels of ALT (P = .005) and AST (P = .033) in a dominant model, which were consistent with a tendency toward increased TB risk.
Causality:No
Causal Description:
Clinical-realted Application: